Ontology highlight
ABSTRACT:
SUBMITTER: Konopacki C
PROVIDER: S-EPMC7534899 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Konopacki Catherine C Pritykin Yuri Y Rubtsov Yury Y Leslie Christina S CS Rudensky Alexander Y AY
Nature immunology 20190114 2
Regulatory T cells (T<sub>reg</sub> cells), whose differentiation and function are controlled by transcription factor Foxp3, express the closely related family member Foxp1. Here we explored Foxp1 function in T<sub>reg</sub> cells. We found that a large number of Foxp3-bound genomic sites in T<sub>reg</sub> cells were occupied by Foxp1 in both T<sub>reg</sub> cells and conventional T cells (T<sub>conv</sub> cells). In T<sub>reg</sub> cells, Foxp1 markedly increased Foxp3 binding to these sites. ...[more]