Disruption of NREM sleep and sleep-related spatial memory consolidation in mice lacking adult hippocampal neurogenesis.

ABSTRACT: Cellular plasticity at the structural level and sleep at the behavioural level are both essential for memory formation. The link between the two is not well understood. A functional connection between adult neurogenesis and hippocampus-dependent memory consolidation during NREM sleep has been hypothesized but not experimentally shown. Here, we present evidence that during a three-day learning session in the Morris water maze task a genetic knockout model of adult neurogenesis (Cyclin D2^-/-) showed changes in sleep macro- and microstructure. Sleep EEG analyses revealed a lower total sleep time and NREM fraction in Cyclin D2^-/- mice as well as an impairment of sleep specific neuronal oscillations that are associated with memory consolidation. Better performance in the m

SUBMITTER: Sippel D 

PROVIDER: S-EPMC7536189 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature