Unknown

Dataset Information

0

Alkylated benzimidazoles: Design, synthesis, docking, DFT analysis, ADMET property, molecular dynamics and activity against HIV and YFV.


ABSTRACT: A series of alkylated benzimidazole derivatives was synthesized and screened for their anti-HIV, anti-YFV, and broad-spectrum antiviral properties. The physicochemical parameters and drug-like properties of the compounds were assessed first, and then docking studies and MD simulations on HIV-RT allosteric sites were conducted to find the possible mode of their action. DFT analysis was also performed to confirm the nature of the hydrogen bonding interaction of active compounds. The in silico studies indicated that the molecules behaved like possible NNRTIs. The nature - polar or non-polar and position of the substituent present at fifth, sixth, and N-1 positions of the benzimidazole moiety played an important role in determining the antiviral properties of the compounds. Among the various compounds, 2-(5,6-dibromo-2-chloro-1H-benzimidazol-1-yl)ethan-1-ol (3a) showed anti-HIV activity with an appreciably low IC50 value as 0.386?×?10-5?M. Similarly, compound 2b, 3-(2-chloro-5-nitro-1H-benzimidazol-1-yl) propan-1-ol, showed excellent inhibitory property against the yellow fever virus (YFV) with EC50 value as 0.7824?×?10-2?M.

SUBMITTER: Srivastava R 

PROVIDER: S-EPMC7537607 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Alkylated benzimidazoles: Design, synthesis, docking, DFT analysis, ADMET property, molecular dynamics and activity against HIV and YFV.

Srivastava Ritika R   Gupta Sunil K SK   Naaz Farha F   Sen Gupta Parth Sarthi PS   Yadav Madhu M   Singh Vishal Kumar VK   Singh Anuradha A   Rana Malay Kumar MK   Gupta Satish Kumar SK   Schols Dominique D   Singh Ramendra K RK  

Computational biology and chemistry 20201006


A series of alkylated benzimidazole derivatives was synthesized and screened for their anti-HIV, anti-YFV, and broad-spectrum antiviral properties. The physicochemical parameters and drug-like properties of the compounds were assessed first, and then docking studies and MD simulations on HIV-RT allosteric sites were conducted to find the possible mode of their action. DFT analysis was also performed to confirm the nature of the hydrogen bonding interaction of active compounds. The in silico stud  ...[more]

Similar Datasets

| S-EPMC9016748 | biostudies-literature
| S-EPMC10839811 | biostudies-literature
| S-EPMC6301267 | biostudies-literature
| S-EPMC9740823 | biostudies-literature
| S-EPMC9044819 | biostudies-literature
| S-EPMC10171978 | biostudies-literature
| S-EPMC8674577 | biostudies-literature
| S-EPMC11292818 | biostudies-literature
| S-EPMC8260667 | biostudies-literature
| S-EPMC7547581 | biostudies-literature