Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.
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ABSTRACT:
SUBMITTER: Wilfong EM
PROVIDER: S-EPMC7537876 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.
Wilfong Erin M EM Croze Roxanne R Fang Xiaohui X Schwede Matthew M Niemi Erene E López Giselle Y GY Lee Jae-Woo JW Nakamura Mary C MC Matthay Michael A MA
PloS one 20201006 10
Human mesenchymal stem/stromal cells (hMSCs) are a promising therapy for acute respiratory distress syndrome (ARDS) and other inflammatory conditions. While considerable research has focused on paracrine effects and mitochondrial transfer that improve lung fluid balance, hMSCs are well known to have immunomodulatory properties as well. Some of these immunomodulatory properties have been related to previously reported paracrine effectors such as indoleamine-2,3-dioxygenase (IDO), but these effect ...[more]
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