Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease.

ABSTRACT:

Objective

To study the neuropathologic correlates of cholinergic basal forebrain (BF) atrophy as determined using antemortem MRI in the Alzheimer disease (AD) spectrum.

Methods

We determined associations between BF volume from antemortem MRI brain scans and postmortem assessment of neuropathologic features, including neuritic plaques, neurofibrillary tangles (NFTs), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer's Disease Neuroimaging Initiative cohort. For comparison, we assessed neuropathologic features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest-based analysis, we determined the association of neuropathologic features with whole brain gray matter volume using regionally unbiased voxel-based volumetry

SUBMITTER: Teipel SJ 

PROVIDER: S-EPMC7538215 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature