Ontology highlight
ABSTRACT:
SUBMITTER: Oshi M
PROVIDER: S-EPMC7538579 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Oshi Masanori M Tokumaru Yoshihisa Y Asaoka Mariko M Yan Li L Satyananda Vikas V Matsuyama Ryusei R Matsuhashi Nobuhisa N Futamura Manabu M Ishikawa Takashi T Yoshida Kazuhiro K Endo Itaru I Takabe Kazuaki K
Scientific reports 20201006 1
Tumor associated macrophages (TAMs) play a critical role in biology of various cancers, including breast cancer. In the current study, we defined "M1" macrophage and "M1"/"M2" ratio by transcriptomic signatures using xCell. We investigated the association between high level of "M1" macrophage or "M1"/"M2" ratio and the tumor immune microenvironment by analyzing the transcriptome of publicly available cohorts, TCGA and METABRIC. We found that "M1" high tumors were not associated with prolonged su ...[more]