Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC7538592 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yang Cuixia C Sheng Yumeng Y Shi Xiaoxing X Liu Yiwen Y He Yiqing Y Du Yan Y Zhang Guoliang G Gao Feng F
Cell death & disease 20201006 10
Most luminal breast carcinomas (BrCas) bearing PIK3CA mutations initially respond to phosphoinositide-3-kinase (PI3K)-α inhibitors, but many eventually become resistant. The underlying mechanisms of this resistance remain obscure. In this work, we showed that a CD44<sup>high</sup> state due to aberrant isoform splicing was acquired from adaptive resistance to a PI3Kα inhibitor (BLY719) in luminal BrCas. Notably, the expression of CD44 was positively correlated with estrogen receptor (ER) activit ...[more]