Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study).
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7538905 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study).
Zhang Yifei Y Gu Yanyun Y Ren Huahui H Wang Shujie S Zhong Huanzi H Zhao Xinjie X Ma Jing J Gu Xuejiang X Xue Yaoming Y Huang Shan S Yang Jialin J Chen Li L Chen Gang G Qu Shen S Liang Jun J Qin Li L Huang Qin Q Peng Yongde Y Li Qi Q Wang Xiaolin X Kong Ping P Hou Guixue G Gao Mengyu M Shi Zhun Z Li Xuelin X Qiu Yixuan Y Zou Yuanqiang Y Yang Huanming H Wang Jian J Xu Guowang G Lai Shenghan S Li Junhua J Ning Guang G Wang Weiqing W
Nature communications 20201006 1
Human gut microbiome is a promising target for managing type 2 diabetes (T2D). Measures altering gut microbiota like oral intake of probiotics or berberine (BBR), a bacteriostatic agent, merit metabolic homoeostasis. We hence conducted a randomized, double-blind, placebo-controlled trial with newly diagnosed T2D patients from 20 centres in China. Four-hundred-nine eligible participants were enroled, randomly assigned (1:1:1:1) and completed a 12-week treatment of either BBR-alone, probiotics+BBR ...[more]
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