Ontology highlight
ABSTRACT:
SUBMITTER: Viviani R
PROVIDER: S-EPMC7539151 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Viviani Roberto R Messina Irene I Bosch Julia E JE Dommes Lisa L Paul Anna A Schneider Katharina L KL Scholl Catharina C Stingl Julia C JC
Translational psychiatry 20201006 1
The polymorphic drug-metabolizing enzyme CYP2D6, which is responsible for the metabolism of most psychoactive compounds, is expressed not only in the liver, but also in the brain. The effects of its marked genetic polymorphism on the individual capacity to metabolize drugs are well known, but its role in metabolism of neural substrates affecting behavior personality or cognition, suggested by its CNS expression, is a long-standing unresolved issue. To verify earlier findings suggesting a potenti ...[more]