Ontology highlight
ABSTRACT:
SUBMITTER: Kuzmin E
PROVIDER: S-EPMC7539174 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kuzmin Elena E VanderSluis Benjamin B Nguyen Ba Alex N AN Wang Wen W Koch Elizabeth N EN Usaj Matej M Khmelinskii Anton A Usaj Mojca Mattiazzi MM van Leeuwen Jolanda J Kraus Oren O Tresenrider Amy A Pryszlak Michael M Hu Ming-Che MC Varriano Brenda B Costanzo Michael M Knop Michael M Moses Alan A Myers Chad L CL Andrews Brenda J BJ Boone Charles C
Science (New York, N.Y.) 20200601 6498
Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mu ...[more]