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High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections.

ABSTRACT: A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; day 3-4, 7.28 ± 1.41; day 5-8, 6.66 ± 1.87 log10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log10 copies/mL increase, 95% confidence interval, 1.03-1.90; P = .034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.

SUBMITTER: Lee N 

PROVIDER: S-EPMC7539363 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections.

Lee Nelson N   Chan Martin C W MC   Lui Grace C Y GC   Li Ran R   Wong Rity Y K RY   Yung Irene M H IM   Cheung Catherine S K CS   Chan Eugenia C Y EC   Hui David S C DS   Chan Paul K S PK  

The Journal of infectious diseases 20150422 8

A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; d  ...[more]

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