Unknown

Dataset Information

0

High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections.

ABSTRACT: A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; day 3-4, 7.28 ± 1.41; day 5-8, 6.66 ± 1.87 log10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log10 copies/mL increase, 95% confidence interval, 1.03-1.90; P = .034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.

SUBMITTER: Lee N 

PROVIDER: S-EPMC7539363 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections.

Lee Nelson N   Chan Martin C W MC   Lui Grace C Y GC   Li Ran R   Wong Rity Y K RY   Yung Irene M H IM   Cheung Catherine S K CS   Chan Eugenia C Y EC   Hui David S C DS   Chan Paul K S PK  

The Journal of infectious diseases 20150422 8

A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; d  ...[more]

Similar Datasets

Unknown Virus-Specific Antibody, Viral Load, and Disease Severity in Respiratory Syncytial Virus Infection.
| S-EPMC6009588 | biostudies-literature
Transcriptomics Transcriptional Profiling is Superior to Procalcitonin to Discriminate Bacterial vs. Viral Lower Respiratory Tract Infections in Hospitalized Adults
2015-09-14 | E-GEOD-60244 | biostudies-arrayexpress
Unknown Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness.
| S-EPMC4038137 | biostudies-literature
Unknown Viral load drives disease in humans experimentally infected with respiratory syncytial virus.
| S-EPMC3001267 | biostudies-literature
Transcriptomics Transcriptional Profiling is Superior to Procalcitonin to Discriminate Bacterial vs. Viral Lower Respiratory Tract Infections in Hospitalized Adults
2015-09-14 | GSE60244 | GEO
Unknown Acute respiratory infections in hospitalized children in Vientiane, Lao PDR - the importance of Respiratory Syncytial Virus.
| S-EPMC5571090 | biostudies-literature
Unknown Respiratory syncytial virus subtype ON1/NA1/BA9 predominates in hospitalized children with lower respiratory tract infections.
| S-EPMC7166484 | biostudies-literature
Unknown Human respiratory syncytial virus and other viral infections in infants receiving palivizumab.
| S-EPMC7172843 | biostudies-literature
Unknown Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection.
| S-EPMC6452299 | biostudies-literature
Unknown The Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Norwegian Children.
| S-EPMC7107394 | biostudies-literature