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Assessment of tear film lipid layer thickness in patients with Meibomian gland dysfunction at different ages.


ABSTRACT: BACKGROUND:To evaluate the correlations between lipid layer thickness (LLT) and morphology and function of the meibomian glands in patients who were diagnosed as meibomian gland dysfunction (MGD) in different age groups. METHODS:Patients who have diagnosed as obstructive MGD were included in this prospective, cross-sectional study. Patients were divided into three groups: young (ages 20-39?years), middle-aged (ages 40-59?years), and older (aged ?60?years). All patients completed an Ocular Surface Disease Index (OSDI) questionnaire and were evaluated for LLT, tear meniscus height (TMH), noninvasive tear film break-up time (NI-BUT) measurement, invasive TBUT (ITBUT), corneal fluoresceinstaining (CFS) score, eyelid margin abnormalities, Schirmer I test, and MG function and morphology, by using the Keratograph 5 and LipiView interferometer. RESULTS:Two hundred and nine patients (209 eyes) were included. The median LLT of all patient was 57?nm (IQR, 36.5?nm), and the LLT values were significantly different among the young group (median, 51?nm; IQR, 23.5?nm), middle-aged group (median, 59.5?nm; IQR 46.5?nm) and older group (median, 62?nm; IQR, 42.5?nm) (P?=?0.033, Kruskal-Wallis test). In regression analyses controlling for confounder factors sex and MG loss, the LLT was positively correlated with age (??=?5.539, P?=?0.001). There was a negative correlation between LLT and MG dropout in the all (r?=?-?0.527, P?

SUBMITTER: Li J 

PROVIDER: S-EPMC7539430 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Assessment of tear film lipid layer thickness in patients with Meibomian gland dysfunction at different ages.

Li Junhua J   Ma Jiling J   Hu Man M   Yu Jianqin J   Zhao Yune Y  

BMC ophthalmology 20201006 1


<h4>Background</h4>To evaluate the correlations between lipid layer thickness (LLT) and morphology and function of the meibomian glands in patients who were diagnosed as meibomian gland dysfunction (MGD) in different age groups.<h4>Methods</h4>Patients who have diagnosed as obstructive MGD were included in this prospective, cross-sectional study. Patients were divided into three groups: young (ages 20-39 years), middle-aged (ages 40-59 years), and older (aged ≥60 years). All patients completed a  ...[more]

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