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DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia


ABSTRACT: Background Epigenetics can contribute to lipid disorders in obesity. The DNA methylation pattern can be the cause or consequence of high blood lipids. The aim of the study was to investigate the DNA methylation profile in peripheral leukocytes associated with elevated LDL-cholesterol level in overweight and obese individuals. Methods To identify the differentially methylated genes, genome-wide DNA methylation microarray analysis was performed in leukocytes of obese individuals with high LDL-cholesterol (LDL-CH, ??3.4 mmol/L) versus control obese individuals with LDL-CH,

SUBMITTER: P?atek T 

PROVIDER: S-EPMC7539457 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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