Ontology highlight
ABSTRACT:
SUBMITTER: Shi J
PROVIDER: S-EPMC7539531 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cell reports 20201001 1
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endothelium, we considered if sphingomyelinase is relevant to endogenous PIEZO1. Patch clamping was used to quantify PIEZO1-mediated signals in freshly isolated murine endothelium exposed to the mechanical forces caused by shear stress and membrane stretch. Neutral sph ...[more]