Adjuvant treatment for high-risk salivary gland malignancies and prognostic stratification based on a 20-year single institution experience.
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ABSTRACT: Background and Aim:Retrospective analysis of the utility of adjuvant radiation (RT) or chemoradiation (CRT) and identify prognostic features for patients with high-risk head and neck salivary gland cancers. Methods:From 1/1997 to 12/2017, 108 patients underwent surgery, and RT (n = 50) or CRT (n = 58) for positive lymph node(s), extracapsular extension, perineural invasion, lymphovascular space invasion, positive/close margin, and/or grade 3 disease. Outcomes were estimated with the Kaplan-Meier method. Significant predictors identified through regression analyses were incorporated into multivariable regression (MVA). Toxicities were compared using chi-square. Results:The median follow-up was 52?months (range: 3-226). The number of risk factors (RFs) between RT and CRT groups were: 0 to 1 (44% vs 7%), 2 to 3 (48% vs 41%), or 4 to 6 (8% vs 52%), respectively (P?
SUBMITTER: Onderdonk BE
PROVIDER: S-EPMC7539565 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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