Ontology highlight
ABSTRACT:
SUBMITTER: van de Moosdijk AAA
PROVIDER: S-EPMC7539917 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
van de Moosdijk Anoeska Agatha Alida AAA van de Grift Yorick Bernardus Cornelis YBC de Man Saskia Madelon Ada SMA Zeeman Amber Lisanne AL van Amerongen Renée R
Genesis (New York, N.Y. : 2000) 20200709 9
Wnt signal transduction controls tissue morphogenesis, maintenance and regeneration in all multicellular animals. In mammals, the WNT/CTNNB1 (Wnt/β-catenin) pathway controls cell proliferation and cell fate decisions before and after birth. It plays a critical role at multiple stages of embryonic development, but also governs stem cell maintenance and homeostasis in adult tissues. However, it remains challenging to monitor endogenous WNT/CTNNB1 signaling dynamics in vivo. Here, we report the gen ...[more]