Ontology highlight
ABSTRACT:
SUBMITTER: Barbier L
PROVIDER: S-EPMC7540323 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Barbier Liese L Ebbers Hans C HC Declerck Paul P Simoens Steven S Vulto Arnold G AG Huys Isabelle I
Clinical pharmacology and therapeutics 20200430 4
To date, no consensus exists among stakeholders about switching patients between reference biological products (RPs) and biosimilars, which may have been curbing the implementation of biosimilars in clinical practice. This study synthesizes the available data on switching and assesses whether switching patients from a RP to its biosimilar or vice versa affects efficacy, safety, or immunogenicity outcomes. A total of 178 studies, in which switch outcomes from a RP to a biosimilar were reported, w ...[more]