High-risk lymph node ratio predicts worse prognosis in patients with locally advanced oral cancer.

ABSTRACT:

Background

To investigate the prognostic value of lymph node ratio (LNR), as well as the correlation with docetaxel, cisplatin, and 5-FU (TPF) induction chemotherapy, in patients with locally advanced oral squamous cell carcinoma (OSCC).

Methods

Two-hundred and forty-five patients from a phase 3 trial involving TPF induction chemotherapy in stage III/IVA OSCC patients (NCT01542931) were enrolled in this study between 2008 and 2010. The clinical and pathological data were collected and analyzed. The cutoff value for LNR was calculated on the receiver operating characteristic (ROC) curve. Univariate and multivariate Cox regression models, and Kaplan-Meier method were used for survival analysis.

Results

According to the ROC curve, the cutoff value for LNR was 7.6%. With

SUBMITTER: Zhao TC 

PROVIDER: S-EPMC7540480 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature