Ontology highlight
ABSTRACT:
SUBMITTER: Kolano L
PROVIDER: S-EPMC7540576 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kolano Lisa L Knappe Daniel D Volke Daniela D Sträter Norbert N Hoffmann Ralf R
Chembiochem : a European journal of chemical biology 20200630 18
Proline-rich antimicrobial peptides expressed in insects are primarily active against Enterobacteriaceae. Mechanistically, they target the bacterial (70S) ribosome after partially transporter-based cellular uptake, as revealed for Api137 and Onc112 on Escherichia coli. Following molecular modeling indicating that the Onc112 contact site is conserved among the ribosomes of high-priority pathogens, the ribosome binding of Api137 and Onc112 was studied. The dissociation constants (K<sub>d</sub> ) o ...[more]