Ontology highlight
ABSTRACT:
SUBMITTER: Lovering RM
PROVIDER: S-EPMC7541569 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lovering Richard M RM Iyer Shama R SR Edwards Benjamin B Davies Kay E KE
Neuroscience letters 20200817
The focus of this review is on Duchenne muscular dystrophy (DMD), which is caused by the absence of the protein dystrophin and is characterized as a neuromuscular disease in which muscle weakness, increased susceptibility to muscle injury, and inadequate repair appear to underlie the pathology. Considerable attention has been dedicated to studying muscle fiber damage, but data show that both human patients and animal models for DMD present with fragmented neuromuscular junction (NMJ) morphology. ...[more]