Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis.

ABSTRACT:

Objective

Inhibition of hedgehog (HH) signaling prevents cartilage degeneration and promotes repair in animal models of osteoarthritis (OA). This study, undertaken in OA models and in human OA articular cartilage, was designed to explore whether kappa opioid receptor (KOR) modulation via the inhibition of HH signaling may have therapeutic potential for achieving disease-modifying activity in OA.

Methods

Primary human articular cartilage and synovial tissue samples from patients with knee OA undergoing total joint replacement and from healthy human subjects were obtained from the National Disease Research Interchange. For in vivo animal studies, a partial medial meniscectomy (PMM) model of knee OA in rats was used. A novel automated 3-dimensional indentation tester (Mach-1) w

SUBMITTER: Weber AE 

PROVIDER: S-EPMC7541630 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature