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Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study.

ABSTRACT: The viral RNA shedding time (VST) for severe acute respiratory syndrome coronavirus 2 has not been well characterized. Clinical data were collected and compared between patients with short and long VSTs (in the lower and upper quartiles, respectively). The probability of recurrent positive reverse-transcription polymerase chain reaction results decreased sharply to 4.8% after 3 consecutive negative results. A series of ?3 consecutive negative results was suitable as a criterion for the end of viral RNA shedding. The VST for shedding from the respiratory tract was significantly shorter in patients with normal B-cell counts on admission than in those with decreased B-cell counts (median [interquartile range], 11 [9-13] vs 16 [12-20] days, respectively; P?=?.001).

SUBMITTER: Hao S 

PROVIDER: S-EPMC7542891 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study.

Hao Shaorui S   Lian Jiangshan J   Lu Yingfeng Y   Jia Hongyu H   Hu Jianhua J   Yu Guodong G   Wang Xiaoyan X   Xu Kaijin K   Ni Qin Q   Li Yongtao Y   Liu Jun J   Zhao Hong H   Zhang Xuan X   Yu Liang L   Yu Xiaopeng X   Xiang Dairong D   Chen Yu Y   Zheng Shufa S   Qiu Yunqing Y   Li Lanjuan L   Liang Tingbo T   Yang Yida Y   Sheng Jifang J  

The Journal of infectious diseases 20200701 3

The viral RNA shedding time (VST) for severe acute respiratory syndrome coronavirus 2 has not been well characterized. Clinical data were collected and compared between patients with short and long VSTs (in the lower and upper quartiles, respectively). The probability of recurrent positive reverse-transcription polymerase chain reaction results decreased sharply to 4.8% after 3 consecutive negative results. A series of ≥3 consecutive negative results was suitable as a criterion for the end of vi  ...[more]

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