Ontology highlight
ABSTRACT:
SUBMITTER: Guan L
PROVIDER: S-EPMC7544145 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Guan Liying L Zhan Zhigao Z Yang Yongzhi Y Miao Yue Y Huang Xun X Ding Mei M
PLoS genetics 20200928 9
ER stress occurs in many physiological and pathological conditions. However, how chronic ER stress is alleviated in specific cells in an intact organism is an outstanding question. Here, overexpressing the gap junction protein UNC-9 (Uncoordinated) in C. elegans neurons triggers the Ire1-Xbp1-mediated stress response in an age-dependent and cell-autonomous manner. The p38 MAPK PMK-3 regulates the chronic stress through IRE-1 phosphorylation. Overexpressing gap junction protein also activates aut ...[more]