Ontology highlight
ABSTRACT:
SUBMITTER: Barrera A
PROVIDER: S-EPMC7544202 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Barrera Aldo A Ramos Hade H Vera-Otarola Jorge J Fernández-García Leandro L Angulo Jenniffer J Olguín Valeria V Pino Karla K Mouland Andrew J AJ López-Lastra Marcelo M
Nucleic acids research 20201001 18
The full-length mRNAs of the human immunodeficiency virus type-1 (HIV-1), the human T-cell lymphotropic virus type-1 (HTLV-1), and the mouse mammary tumor virus (MMTV) harbor IRESs. The activity of the retroviral-IRESs requires IRES-transacting factors (ITAFs), being hnRNP A1, a known ITAF for the HIV-1 IRES. In this study, we show that hnRNP A1 is also an ITAF for the HTLV-1 and MMTV IRESs. The MMTV IRES proved to be more responsive to hnRNP A1 than either the HTLV-1 or the HIV-1 IRESs. The imp ...[more]