Ontology highlight
ABSTRACT: Rationale
Anlotinib has been proved to be effective in advanced refractory non-small cell lung cancer.Patient concerns
A 47-year-old female non-smoker was admitted due to persistent chest tightness for a month.Diagnoses
Epidermal growth factor receptor (EGFR) wild-type advanced primary lung adenocarcinoma without brain or bone metastasis.Interventions
The patient failed 2 lines of pemetrexed/docetaxel plus carboplatin and third-line erlotinib. Fourth-line anlotinib was administered thereafter.Outcomes
The pulmonary lesions showed partial remission 5 months after anlotinib monotherapy. The patient demonstrated a progression-free survival of more than 7 months and an overall survival of >12 months. The adverse events including hypertension and fatigue were well-tolerated.Lessons
Salvage anlotinib might be a reasonable choice in EGFR wild-type lung adenocarcinoma after failure of chemotherapy. Further well-designed trials are warranted to verify this occasional finding.
SUBMITTER: Liu L
PROVIDER: S-EPMC7544372 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Liu Lei L Wang Xiang X Wu Wen-Bin WB Zhang Miao M
Medicine 20201001 41
<h4>Rationale</h4>Anlotinib has been proved to be effective in advanced refractory non-small cell lung cancer.<h4>Patient concerns</h4>A 47-year-old female non-smoker was admitted due to persistent chest tightness for a month.<h4>Diagnoses</h4>Epidermal growth factor receptor (EGFR) wild-type advanced primary lung adenocarcinoma without brain or bone metastasis.<h4>Interventions</h4>The patient failed 2 lines of pemetrexed/docetaxel plus carboplatin and third-line erlotinib. Fourth-line anlotini ...[more]