Ontology highlight
ABSTRACT:
SUBMITTER: Sok P
PROVIDER: S-EPMC7544624 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Sok Péter P Gógl Gergő G Kumar Ganesan Senthil GS Alexa Anita A Singh Neha N Kirsch Klára K Sebő Anna A Drahos László L Gáspári Zoltán Z Peti Wolfgang W Reményi Attila A
Structure (London, England : 1993) 20200709 10
Mitogen-activated protein kinases (MAPKs) control essential eukaryotic signaling pathways. While much has been learned about MAPK activation, much less is known about substrate recruitment and specificity. MAPK substrates may be other kinases that are crucial to promote a further diversification of the signaling outcomes. Here, we used a variety of molecular and cellular tools to investigate the recruitment of two substrate kinases, RSK1 and MK2, to three MAPKs (ERK2, p38α, and ERK5). Unexpected ...[more]