Ontology highlight
ABSTRACT:
SUBMITTER: Pai CH
PROVIDER: S-EPMC7544830 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Pai Chen-Hsueh CH Lin Shu-Rung SR Liu Chia-Hao CH Pan Szu-Yu SY Hsu Hao H Chen Yi-Ting YT Yen Ching-Tzu CT Yu I-Shing IS Wu Hua-Lin HL Lin Shuei-Liong SL Lin Shu-Wha SW
Scientific reports 20201008 1
The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney disease, upregulated CD248 in myofibroblasts is linked to poor renal survival. In this study, we demonstrated a novel interaction between CD248 and macrophages to be a key step in mediating tissue fibrosis. CD248 was upregulated ...[more]