Ontology highlight
ABSTRACT:
SUBMITTER: Guillen L
PROVIDER: S-EPMC7545205 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Guillén Lucía L Padilla Sergio S Fernández Marta M Agulló Vanesa V García José Alberto JA Telenti Guillermo G García-Abellán Javier J Botella Ángela Á Gutiérrez Félix F Masiá Mar M
Scientific reports 20201008 1
Excessive interleukin-6 signaling is a key factor contributing to the cytokine release syndrome implicated in clinical manifestations of COVID-19. Preliminary results suggest that tocilizumab, a humanized monoclonal anti-interleukin-6 receptor antibody, may be beneficial in severely ill patients, but no data are available on earlier stages of disease. An anticipated blockade of interleukin-6 might hypothetically prevent the catastrophic consequences of the overt cytokine storm. We evaluated earl ...[more]