Dataset Information

Altered coupling between resting-state glucose metabolism and functional activity in epilepsy.

ABSTRACT:

Objective

Altered functional activities and hypometabolism have been found in medial temporal lobe epilepsy patients with hippocampal sclerosis (mTLE-HS). Hybrid PET/MR scanners provide opportunities to explore the relationship between resting-state energy consumption and functional activities, but whether repeated seizures disturb the bioenergetic coupling and its relationship with seizure outcomes remain unknown.

Methods

¹⁸ F-FDG PET and resting-state functional MRI (rs-fMRI) scans were performed with hybrid PET/MR in 26 patients with mTLE-HS and in healthy controls. Energy consumption was quantified by ¹⁸ F-FDG standardized uptake value ratio(SUVR) relative to cerebellum. Spontaneous neural activities were estimated using regional homogeneity (ReHo), fractional amplitude of low frequency fluctuations (fALFF) from rs-fMRI. Between-group differences in SUVR and rs-fMRI derived metrics were evaluated by two-sample t test. Voxel-wise spatial correlations were explored between SUVR and ReHo, fALFF across gray matter and compared between groups. Furthermore, the relationships between altered fALFF/SUVR and ReHo/SUVR coupling and surgical outcomes were evaluated.

Results

Both the patients and healthy controls showed significant positive correlations between SUVR and rs-fMRI metrics. Spatial correlations between SUVR and fMRI-derived metrics across gray matter were significantly higher in patients with mTLE-HS compared with healthy controls (fALFF/SUVR, P < 0.001; ReHo/SUVR, P = 0.022). Higher fALFF/SUVR couplings were found in patients who had Engel class IA after surgery than all other (P = 0.025), while altered ReHo/SUVR couplings (P = 0.097) were not.

Conclusion

These findings demonstrated altered bioenergetic coupling across gray matter and its relationship with seizure outcomes, which may provide novel insights into pathogenesis of mTLE-HS and potential biomarkers for epilepsy surgery planning.

SUBMITTER: Wang J

PROVIDER: S-EPMC7545617 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Altered coupling between resting-state glucose metabolism and functional activity in epilepsy.

Wang Jingjuan J Shan Yi Y Dai Jindong J Cui Bixiao B Shang Kun K Yang Hongwei H Chen Zhongwei Z Shan Baoci B Zhao Guoguang G Lu Jie J

Annals of clinical and translational neurology 20200829 10

<h4>Objective</h4>Altered functional activities and hypometabolism have been found in medial temporal lobe epilepsy patients with hippocampal sclerosis (mTLE-HS). Hybrid PET/MR scanners provide opportunities to explore the relationship between resting-state energy consumption and functional activities, but whether repeated seizures disturb the bioenergetic coupling and its relationship with seizure outcomes remain unknown.<h4>Methods</h4><sup>18</sup> F-FDG PET and resting-state functional MRI ( ...[more]

PMID: 32860354

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Dataset Information

Altered coupling between resting-state glucose metabolism and functional activity in epilepsy.

Objective

Methods

Results

Conclusion

Publications

Altered coupling between resting-state glucose metabolism and functional activity in epilepsy.

Similar Datasets

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