Ontology highlight
ABSTRACT:
SUBMITTER: Tejera D
PROVIDER: S-EPMC7546125 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Tejera Dalissa D Kushnirsky Marina M Gultekin Sakir H SH Lu Min M Steelman Lori L de la Fuente Macarena I MI
CNS oncology 20200727 3
Glioblastoma is the most common and aggressive primary brain tumor. Despite standard multimodality therapy, median overall survival remains poor with a 5-year survival rate of approximately 5% in most studies (range 4.7-13.0%). Strong interest in targeting IDH mutations has led to a variety of studies in both hematologic malignancies and solid tumors and to the approval of IDH inhibitors such as ivosidenib, an IDH1 inhibitor, in hematologic malignancies. Here, we present the first case study of ...[more]