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Fecal, oral, blood and skin virome of laboratory rabbits.


ABSTRACT: Here, we investigated the fecal, oral, blood, and skin virome of 10 laboratory rabbits using a viral metagenomic method. In the oral samples, we detected a novel polyomavirus (RabPyV), and phylogenetic analysis based on the large T antigen, VP1 and VP2 regions indicated that the novel strain might have undergone a recombination event. Recombination analysis based on related genomes confirmed that RabPyV is a multiple recombinant between rodent-like and avian-like polyomaviruses. In fecal samples, three partial or complete genome sequences of viruses belonging to the families Picobirnaviridae, Parvoviridae, Microviridae and Coronaviridae were characterized, and phylogenetic trees were constructed based on the predicted amino acid sequences of viral proteins. This study increases the amount of genetic information on viruses present in laboratory rabbits.

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC7546134 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Fecal, oral, blood and skin virome of laboratory rabbits.

Xiao Yuqing Y   Wang Hao H   Feng Lei L   Pan Jiamin J   Chen Zeyu Z   Wang Huiling H   Yang Shixing S   Shen Quan Q   Wang Xiaochun X   Shan Tongling T   Zhang Wen W  

Archives of virology 20201009 12


Here, we investigated the fecal, oral, blood, and skin virome of 10 laboratory rabbits using a viral metagenomic method. In the oral samples, we detected a novel polyomavirus (RabPyV), and phylogenetic analysis based on the large T antigen, VP1 and VP2 regions indicated that the novel strain might have undergone a recombination event. Recombination analysis based on related genomes confirmed that RabPyV is a multiple recombinant between rodent-like and avian-like polyomaviruses. In fecal samples  ...[more]

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