Ontology highlight
ABSTRACT: Background
As of 2013, more than 550,000 people are living with non-Hodgkin lymphoma (NHL).Patients and methods
We undertook a large Surveillance Epidemiology and End Results (SEER) based analysis to describe outcome disparities in different subgroups of aggressive T-cell and B-cell NHL patients, with a focus on various ethnicities.Results
The final analysis included 7662 patients with T-cell and 84,910 with B-cell NHL. Survival analysis revealed that male sex and increasing age were independent predictors of worse overall survival (OS; P < .001). For aggressive T-cell NHL, there was no significant improvement in median OS between 1973 and 2011 (P = .081), and ethnic minorities (Asians, Hispanics, and African Americans) had significantly worse OS than whites (P < .001). There were similar trends for age, sex, and race for diffuse large B-cell NHL, but a significant improvement in median OS was seen over time (P < .001).Conclusion
These results are the first to elicit outcomes in a broad classification of ethnic minorities and underscore the urgency for development of novel therapeutics, especially in T-cell NHL. In addition, in-depth studies of disease biology and health care utilization are required for better triage of health care resources, especially for ethnic minorities.
SUBMITTER: Crozier JA
PROVIDER: S-EPMC7546202 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Crozier Jennifer A JA Sher Taimur T Yang Dongyun D Swaika Abhisek A Foran James J Ghosh Radhika R Tun Han H Colon-Otero Gerardo G Kelly Kevin K Chanan-Khan Asher A Ailawadhi Sikander S
Clinical lymphoma, myeloma & leukemia 20150619 10
<h4>Background</h4>As of 2013, more than 550,000 people are living with non-Hodgkin lymphoma (NHL).<h4>Patients and methods</h4>We undertook a large Surveillance Epidemiology and End Results (SEER) based analysis to describe outcome disparities in different subgroups of aggressive T-cell and B-cell NHL patients, with a focus on various ethnicities.<h4>Results</h4>The final analysis included 7662 patients with T-cell and 84,910 with B-cell NHL. Survival analysis revealed that male sex and increas ...[more]