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Multichannel parallel processing of neural signals in memristor arrays.

ABSTRACT: Fully implantable neural interfaces with massive recording channels bring the gospel to patients with motor or speech function loss. As the number of recording channels rapidly increases, conventional complementary metal-oxide semiconductor (CMOS) chips for neural signal processing face severe challenges on parallelism scalability, computational cost, and power consumption. In this work, we propose a previously unexplored approach for parallel processing of multichannel neural signals in memristor arrays, taking advantage of their rich dynamic characteristics. The critical information of neural signal waveform is extracted and encoded in the memristor conductance modulation. A signal segmentation scheme is developed to adapt to device variations. To verify the fidelity of the processed results, seizure prediction is further demonstrated, with high accuracy above 95% and also more than 1000× improvement in power efficiency compared with CMOS counterparts. This work suggests that memristor arrays could be a promising multichannel signal processing module for future implantable neural interfaces.

SUBMITTER: Liu Z

PROVIDER: S-EPMC7546699 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Multichannel parallel processing of neural signals in memristor arrays.

Liu Zhengwu Z Tang Jianshi J Gao Bin B Li Xinyi X Yao Peng P Lin Yudeng Y Liu Dingkun D Hong Bo B Qian He H Wu Huaqiang H

Science advances 20201009 41

Fully implantable neural interfaces with massive recording channels bring the gospel to patients with motor or speech function loss. As the number of recording channels rapidly increases, conventional complementary metal-oxide semiconductor (CMOS) chips for neural signal processing face severe challenges on parallelism scalability, computational cost, and power consumption. In this work, we propose a previously unexplored approach for parallel processing of multichannel neural signals in memrist ...[more]

PMID: 33036975

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Project description:PurposeMultichannel Transcranial Magnetic Stimulation (mTMS) arrays enable multiple sites to be stimulated simultaneously or sequentially under electronic control without moving the system's stimulation coils. Here, we build and characterize the performance of a novel modular 3-axis TMS coil that can be utilized as a unit element in large-scale multichannel TMS arrays.MethodsWe determined the basic physical characteristics of the 3-axis TMS coil x-, y- and z-elements using a custom 2-channel programmable stimulator prototype. We mapped the temporal rate-of-change of the induced magnetic field (dB/dt) on a 2D plane parallel to the coil surface (including an extended line for full spatial coverage) and compared those values with predictions from magnetic field simulations. Temperature measurements were carried out to assess the incorporated air-cooling method. We measured the mutual and self-inductances of the x/y/z-elements to assess coupling between them. Additionally, we measured and calculated the coupling between z-elements in the array configuration. Finally, we performed electric field simulations to evaluate the stimulation intensity and focality of the coil and compared the results to conventional TMS coils as well as demonstrated suitability of the 3-axis coil for a multichannel array configuration.ResultsThe experimentally obtained dB/dt values validated the computational model of the 3-axis coil and therefore confirmed that both the coil and stimulator system are operating as intended. The air-cooling system was effective for brief high-frequency pulse trains and extended single- and paired-pulse TMS protocols. The electromagnetic simulations suggested that an array of the 3-axis coils would have comparable stimulation intensity to conventional TMS coils, therefore enabling clearly suprathreshold stimulation of the human brain. The recorded coil coupling between the x/y/z-elements was < 1% and the maximal coupling between z-elements in the array configuration was 1.8% and 3.4% for the measured and calculated values, respectively.ConclusionWe presented a 3-axis coil intended for multichannel TMS arrays. The electromagnetic measurements and simulations verified that the coil fabrication met the desired specifications and that the inductive coupling between the elements was negligible. The air-cooled 3-axis TMS coil appears suitable to be used as an element in multichannel TMS arrays.

Project description:Accumulating evidence suggests that childhood maltreatment (CM) confers risk for psychopathology later in life by inducing hypervigilance to social threat cues such as fearful faces. However, it remains unclear whether the modulatory impact of CM extents to the olfactory domain of social communication in humans. To address this question, we examined whether CM modulates the neural processing of chemosensory threat signals in sweat and whether CM affects the stress-reducing effects of oxytocin (OXT) in this context. In a randomized, double-blind within-subject functional MRI study design, 58 healthy participants (30 females) received intranasal OXT (40 IU) or placebo (PLC) and completed a forced-choice emotion recognition task with faces of varying emotion intensities (neutral to fearful) while exposed to sweat stimuli and a non-social control odor. Axillary sweat samples were collected from 30 healthy male donors undergoing an acute psychosocial stressor (stress) and ergometer training (sport) as control in a pre-study. CM was assessed by the 25-item Childhood Trauma Questionnaire (CTQ). The final fMRI analysis included 50 healthy participants (26 females). Regression analysis showed a stress-specific association of CTQ scores with amygdala hyperreactivity, hippocampal deactivation, and increased functional connectivity between the amygdala and the hippocampus, medial orbitofrontal cortex, and the anterior cingulate cortex (ACC) under PLC. Furthermore, we observed a positive association of CTQ scores and the dampening effects of OXT on stress-related amygdala responses. Our findings suggest that CM may induce hypervigilance to chemosensory threat cues in a healthy sample due to inefficient frontolimbic inhibition of amygdala activation. Future studies should investigate whether increased recruitment of the intralimbic amygdala-hippocampus complex reflects a compensatory mechanism that prevents the development of psychopathology in those who have experienced CM. Furthermore, the results reveal that the stress-specific effects of OXT in the olfactory domain are more pronounced in participants with increasing levels of CM exposure.

Dataset Information

Multichannel parallel processing of neural signals in memristor arrays.

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Multichannel parallel processing of neural signals in memristor arrays.

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