Ontology highlight
ABSTRACT:
SUBMITTER: Dos Santos M
PROVIDER: S-EPMC7547110 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Dos Santos Matthieu M Backer Stéphanie S Saintpierre Benjamin B Izac Brigitte B Andrieu Muriel M Letourneur Franck F Relaix Frederic F Sotiropoulos Athanassia A Maire Pascal P
Nature communications 20201009 1
Skeletal muscle fibers are large syncytia but it is currently unknown whether gene expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq and snATAC-seq that slow, fast, myotendinous and neuromuscular junction myonuclei each have different transcriptional programs, associated with distinct chromatin states and combinations of transcription factors. In adult mice, identified myofiber types predominantly express either a slow or one of the three fast isoforms of M ...[more]