Ontology highlight
ABSTRACT:
SUBMITTER: Capasso D
PROVIDER: S-EPMC7547386 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Capasso Domenica D Borbone Nicola N Terracciano Monica M Di Gaetano Sonia S Piccialli Vincenzo V
Marine drugs 20200729 8
Mycalin A, a polybrominated C<sub>15</sub> acetogenin isolated from the encrusting sponge <i>Mycale rotalis</i>, displays an antiproliferative activity on human melanoma (A375) and cervical adenocarcinoma (HeLa) cells and induces cell death by an apoptotic mechanism. Various analogues and degraded derivatives of the natural substance have been prepared. A modification of the left-hand part of the molecule generates the most active substances. A structurally simplified lactone derivative of mycal ...[more]