Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population.

ABSTRACT: BACKGROUND:lncRNA MIR17HG was upregulated in glioma, and participated in promoting proliferation, migration and invasion of glioma. However, the role of MIR17HG polymorphisms in the occurrence and prognosis of glioma is still unclear. METHODS:In the study, 592 glioma patients and 502 control subjects were recruited. Agena MassARRAY platform was used to detect the genotype of MIR17HG polymorphisms. Logistic regression analysis was used to evaluate the relationship between MIR17HG single nucleotide polymorphisms (SNPs) and glioma risk by odds ratio (OR) and 95% confidence intervals (CIs). Kaplan-Meier curves, Cox hazards models were performed for assessing the role of these SNPs in glioma prognosis by hazard ratios (HR) and 95% CIs. RESULTS:We found that rs7318578 (OR?=?2.25, p?=?3.18?×?10-?5) was significantly associated with glioma susceptibility in the overall participants. In the subgroup with age?

SUBMITTER: Feng J 

PROVIDER: S-EPMC7547478 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature