The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications.

ABSTRACT: The current pandemic of novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) poses a significant global public health threat. While urgent regulatory measures in control of the rapid spread of this virus are essential, scientists around the world have quickly engaged in this battle by studying the molecular mechanisms and searching for effective therapeutic strategies against this deadly disease. At present, the exact mechanisms of programmed cell death upon SARS-CoV-2 infection remain to be elucidated, though there is increasing evidence suggesting that cell death pathways play a key role in SARS-CoV-2 infection. There are several types of programmed cell death, including apoptosis, pyroptosis, and necroptosis. These distinct programs are largely controlled by the proteins of

SUBMITTER: Ivanisenko NV 

PROVIDER: S-EPMC7547561 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature