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Concepts of extracellular matrix remodelling in tumour progression and metastasis.

ABSTRACT: Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.

SUBMITTER: Winkler J

PROVIDER: S-EPMC7547708 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Concepts of extracellular matrix remodelling in tumour progression and metastasis.

Winkler Juliane J Abisoye-Ogunniyan Abisola A Metcalf Kevin J KJ Werb Zena Z

Nature communications 20201009 1

Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase ...[more]

PMID: 33037194

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