Ontology highlight
ABSTRACT:
SUBMITTER: Lim S
PROVIDER: S-EPMC7548284 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lim Sera S Kim Yesol Y Lee Soo-Been SB Kang Hyeok-Gu HG Kim Da-Hyun DH Park Jee Won JW Chung Daeun D Kong Hyunkyung H Yoo Kyung Hyun KH Kim Yonghwan Y Han Wonshik W Chun Kyung-Hee KH Park Jong Hoon JH
Oncogenesis 20201011 10
Checkpoint kinase 1 (Chk1) expression is enhanced in most cancers owing to oncogenic activation and constant replicative stress. Chk1 inactivation is a promising cancer therapy, as its inactivation leads to genomic instability, chromosomal catastrophe, and cancer cell death. Herein, we observed that miR-320c, downregulated in triple-negative breast cancer (TNBC) patients, can target Chk1. In addition, downregulated miR-320c expression was associated with poor overall survival in TNBC patients. A ...[more]