Unknown

Dataset Information

0

Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging.


ABSTRACT: AIM:Human Immunodeficiency Virus (HIV) patients commonly experience dyspnea for which an immediate cause may not be always apparent. In this prospective cohort study of HIV patients with exercise limitation, we use cardiopulmonary exercise testing (CPET) coupled with exercise cardiovascular magnetic resonance (CMR) to elucidate etiologies of dyspnea. METHODS AND RESULTS:Thirty-four HIV patients on antiretroviral therapy with dyspnea and exercise limitation (49.7?years, 65% male, mean absolute CD4 count 700) underwent comprehensive evaluation with combined rest and maximal exercise treadmill CMR and CPET. The overall mean oxygen consumption (VO2) peak was reduced at 23.2 ± 6.9?ml/kg/min with 20 patients (58.8% of overall cohort) achieving a respiratory exchange ratio?>?1. The ventilatory efficiency (VE)/VCO2 slope was elevated at 36 ± 7.92, while ventilatory reserve (VE: maximal voluntary ventilation (MVV)) was within normal limits. The mean absolute right ventricular (RV) and left ventricular (LV) contractile reserves were preserved at 9.0% ± 11.2 and 9.4% ± 9.4, respectively. The average resting and post-exercise mean average pulmonary artery velocities were 12.2 ± 3.9?cm/s and 18.9 ± 8.3 respectively, which suggested lack of exercise induced pulmonary artery hypertension (PAH). LV but not RV delayed enhancement were identified in five patients. Correlation analysis found no relationship between peak VO2 measures of contractile RV or LV reserve, but LV and RV stroke volume correlated with PET CO2 (p?=?0.02, p?=?0.03). CONCLUSION:Well treated patients with HIV appear to have conserved RV and LV function, contractile reserve and no evidence of exercise induced PAH. However, we found evidence of impaired ventilation suggesting a non-cardiopulmonary etiology for dyspnea.

SUBMITTER: Patterson AJ 

PROVIDER: S-EPMC7549205 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging.

Patterson Andrew J AJ   Sarode Anuja A   Al-Kindi Sadeer S   Shaver Lauren L   Thomas Rahul R   Watson Evelyn E   Alaiti Mohamad Amer MA   Liu Yuchi Y   Hamilton Jessie J   Seiberlich Nicole N   Rashid Imran I   Gilkeson Robert R   Schilz Robert R   Hoit Brian B   Jenkins Trevor T   Zullo Melissa M   Bossone Eduardo E   Longenecker Christopher C   Simonetti Orlando O   Rajagopalan Sanjay S  

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20201012 1


<h4>Aim</h4>Human Immunodeficiency Virus (HIV) patients commonly experience dyspnea for which an immediate cause may not be always apparent. In this prospective cohort study of HIV patients with exercise limitation, we use cardiopulmonary exercise testing (CPET) coupled with exercise cardiovascular magnetic resonance (CMR) to elucidate etiologies of dyspnea.<h4>Methods and results</h4>Thirty-four HIV patients on antiretroviral therapy with dyspnea and exercise limitation (49.7 years, 65% male, m  ...[more]

Similar Datasets

| S-EPMC7487601 | biostudies-literature
| S-EPMC8203725 | biostudies-literature
| S-EPMC8713485 | biostudies-literature
| S-EPMC7253557 | biostudies-literature
| S-EPMC5015300 | biostudies-literature
| S-EPMC9582287 | biostudies-literature
| S-EPMC8554852 | biostudies-literature
| S-EPMC7784921 | biostudies-literature
| S-EPMC5745904 | biostudies-literature
| S-EPMC10057087 | biostudies-literature