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Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium.


ABSTRACT: Childhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-based drugs, head or brain radiotherapy, or both have an increased risk of ototoxicity (hearing loss, tinnitus, or both). To ensure optimal care and reduce consequent problems-such as speech and language, social-emotional development, and learning difficulties-for these CAYA cancer survivors, clinical practice guidelines for monitoring ototoxicity are essential. The implementation of surveillance across clinical settings is hindered by differences in definitions of hearing loss, recommendations for surveillance modalities, and remediation. To address these deficiencies, the International Guideline Harmonization Group organised an international multidisciplinary panel, including 32 experts from ten countries, to evaluate the quality of evidence for ototoxicity following platinum-based chemotherapy and head or brain radiotherapy, and formulate and harmonise ototoxicity surveillance recommendations for CAYA cancer survivors.

SUBMITTER: Clemens E 

PROVIDER: S-EPMC7549756 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium.

Clemens Eva E   van den Heuvel-Eibrink Marry M MM   Mulder Renée L RL   Kremer Leontien C M LCM   Hudson Melissa M MM   Skinner Roderick R   Constine Louis S LS   Bass Johnnie K JK   Kuehni Claudia E CE   Langer Thorsten T   van Dalen Elvira C EC   Bardi Edith E   Bonne Nicolas-Xavier NX   Brock Penelope R PR   Brooks Beth B   Carleton Bruce B   Caron Eric E   Chang Kay W KW   Johnston Karen K   Knight Kristin K   Nathan Paul C PC   Orgel Etan E   Prasad Pinki K PK   Rottenberg Jan J   Scheinemann Katrin K   de Vries Andrica C H ACH   Walwyn Thomas T   Weiss Annette A   Am Zehnhoff-Dinnesen Antoinette A   Cohn Richard J RJ   Landier Wendy W  

The Lancet. Oncology 20190101 1


Childhood, adolescent, and young adult (CAYA) cancer survivors treated with platinum-based drugs, head or brain radiotherapy, or both have an increased risk of ototoxicity (hearing loss, tinnitus, or both). To ensure optimal care and reduce consequent problems-such as speech and language, social-emotional development, and learning difficulties-for these CAYA cancer survivors, clinical practice guidelines for monitoring ototoxicity are essential. The implementation of surveillance across clinical  ...[more]

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