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ABSTRACT: Backgrounds
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients' outcomes.Methods
This study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardiac injury was defined as an abnormality in one of the following result markers: 1) myocardial damage marker (creatine kinase-MB or troponin-I), 2) heart failure marker (N-terminal-pro B-type natriuretic peptide), and 3) electrical abnormality marker (electrocardiography). The relationship between each cardiac injury marker and mortality was evaluated. Survival analysis of mortality according to the scoring by numbers of cardiac injury markers was also performed.Results
A total of 38 patients with COVID-19 were enrolled. Twenty-two patients (57.9%) had at least one of cardiac injury markers. The patients with cardiac injuries were older (69.6 ± 14.9 vs. 58.6 ± 13.9 years old, P = 0.026), and were more male (59.1% vs. 18.8%, P = 0.013). They showed lower initial oxygen saturation (92.8 vs. 97.1%, P = 0.002) and a trend toward higher mortality (27.3 vs. 6.3%, P = 0.099). The increased number of cardiac injury markers was significantly related to a higher incidence of in-hospital mortality which was also evidenced by Kaplan-Meier survival analysis (P = 0.008).Conclusion
The increased number of cardiac injury markers is related to in-hospital mortality in patients with COVID-19.
SUBMITTER: Kim IC
PROVIDER: S-EPMC7550234 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kim In Cheol IC Song Jin Eun JE Lee Hee Jung HJ Park Jeong Ho JH Hyun Miri M Lee Ji Yeon JY Kim Hyun Ah HA Kwon Yong Shik YS Park Jae Seok JS Youn Jong Chan JC Hwang Jongmin J Lee Cheol Hyun CH Cho Yun Kyeong YK Park Hyoung Seob HS Yoon Hyuck Jun HJ Nam Chang Wook CW Han Seongwook S Hur Seung Ho SH Eisen Howard J HJ Kim Hyungseop H
Journal of Korean medical science 20201012 39
<h4>Backgrounds</h4>The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients' outcomes.<h4>Methods</h4>This study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardi ...[more]