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Reducing the Toxicity of Long-Term Glucocorticoid Treatment in Large Vessel Vasculitis.

ABSTRACT: PURPOSE:While glucocorticoids (GCs) are effective in large vessel vasculitis (LVV), they may cause serious adverse events (AEs), especially if taken for longer durations and at higher doses. Unfortunately, patients suffering from LVV often need long-term treatment with GCs; therefore, toxicity needs to be expected and countered. RECENT FINDINGS:GCs remain the mainstay of therapy for both giant cell arteritis and Takayasu arteritis. In order to minimize their toxicity, the following strategies should be considered: GC tapering, administration of conventional synthetic (e.g., methotrexate) or biologic (e.g., tocilizumab) GC-sparing agents, as well as monitoring, prophylaxis, and treatment of GC-related AEs. Several drugs are currently under investigation to expand the armamentarium for the treatment of LVV. GC treatment in LVV is effective but associated with toxicity. Strategies to minimize this toxicity should be applied when treating patients suffering from LVV.

SUBMITTER: Palmowski A

PROVIDER: S-EPMC7550368 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Reducing the Toxicity of Long-Term Glucocorticoid Treatment in Large Vessel Vasculitis.

Palmowski Andriko A Buttgereit Frank F

Current rheumatology reports 20201012 12

<h4>Purpose</h4>While glucocorticoids (GCs) are effective in large vessel vasculitis (LVV), they may cause serious adverse events (AEs), especially if taken for longer durations and at higher doses. Unfortunately, patients suffering from LVV often need long-term treatment with GCs; therefore, toxicity needs to be expected and countered.<h4>Recent findings</h4>GCs remain the mainstay of therapy for both giant cell arteritis and Takayasu arteritis. In order to minimize their toxicity, the followin ...[more]

PMID: 33047263

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