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A method to control terpineol production from turpentine by acid catalysts mixing.

ABSTRACT: Terpineol, a promising valorisation product of pine industry, is widely used as an active ingredient for disinfectant soap, cleansers, perfumes, and pharmaceutical purposes. Synthesis of terpineol is generally carried out by separation of ?-pinene compounds from crude turpentine through fractionation and then hydrated (addition of water) with the help of acid catalysts. However, direct turpentine hydration without pre-fractionation process can be more beneficial from economic and process point of views. This study aims to investigate the effect of both single and mixed/combined catalysts towards terpineol yield. Combined strong and weak acid catalysts were required to obtain high feed conversion and terpineol yield. The selectivity of terpineol is then correlated to the solubility of a weak/organic acid. In this study, the highest yield of terpineol was 54.0 ± 8.2%-w/w using combination of formic acid and sulphuric acid.

SUBMITTER: Prakoso T

PROVIDER: S-EPMC7550928 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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A method to control terpineol production from turpentine by acid catalysts mixing.

Prakoso Tirto T Putra Ilham Ardiyanto IA Handojo Lienda L Soerawidjaja Tatang Hernas TH Winoto Haryo Pandu HP Indarto Antonius A

Heliyon 20201008 10

Terpineol, a promising valorisation product of pine industry, is widely used as an active ingredient for disinfectant soap, cleansers, perfumes, and pharmaceutical purposes. Synthesis of terpineol is generally carried out by separation of α-pinene compounds from crude turpentine through fractionation and then hydrated (addition of water) with the help of acid catalysts. However, direct turpentine hydration without pre-fractionation process can be more beneficial from economic and process point o ...[more]

PMID: 33083585

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Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory.

Project description:BACKGROUND:Alpha-Terpineol (?-Terpineol), a C10 monoterpenoid alcohol, is widely used in the cosmetic and pharmaceutical industries. Construction Saccharomyces cerevisiae cell factories for producing monoterpenes offers a promising means to substitute chemical synthesis or phytoextraction. RESULTS:?-Terpineol was produced by expressing the truncated ?-Terpineol synthase (tVvTS) from Vitis vinifera in S. cerevisiae. The ?-Terpineol titer was increased to 0.83 mg/L with overexpression of the rate-limiting genes tHMG1, IDI1 and ERG20F96W-N127W. A GSGSGSGSGS linker was applied to fuse ERG20F96W-N127W with tVvTS, and expressing the fusion protein increased the ?-Terpineol production by 2.87-fold to 2.39 mg/L when compared with the parental strain. In addition, we found that farnesyl diphosphate (FPP) accumulation by down-regulation of ERG9 expression and deletion of LPP1 and DPP1 did not improve ?-Terpineol production. Therefore, ERG9 was overexpressed and the ?-Terpineol titer was further increased to 3.32 mg/L. The best ?-Terpineol producing strain LCB08 was then used for batch and fed-batch fermentation in a 5 L bioreactor, and the production of ?-Terpineol was ultimately improved to 21.88 mg/L. CONCLUSIONS:An efficient ?-Terpineol production cell factory was constructed by engineering the S. cerevisiae mevalonate pathway, and the metabolic engineering strategies could also be applied to produce other valuable monoterpene compounds in yeast.

| S-EPMC6757357 | biostudies-literature

High Add Valued Application of Turpentine in Crop Production through Structural Modification and QSAR Analysis.

Project description:Turpentine is a volatile component of resin, which is an abundant forest resource in Southern China. As one of the most important components, the integrated application of ?-pinene has been studied. The broad-spectrum evaluation of ?-pinene and its analogues has, therefore, been necessary. In an attempt to expand the scope of agro-activity trials, the preparation and the evaluation of the herbicidal activity of a series of ?-pinene analogues against three agricultural herbs were carried out. In accordance with the overall herbicidal activity, it is noteworthy that compounds 6k, 6l, and 6m demonstrated extreme activity with IC50 values of 0.065, 0.065, and 0.052 mol active ingredients/hectare against E. crus-galli. The preliminary structure-activity relationship (SAR) was analyzed and the compounds with the appropriate volatility and substituent type that had beneficial herbicidal activity were analyzed. Simultaneously, the quantitative structure-activity relationship (QSAR) model was built and the most important structural features were indicated, which was, to a certain extent, in line with the SAR study. The study aimed to study the application of the forest resource turpentine in agriculture as a potential and alternative approach for comprehensive utilization.

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