Ontology highlight
ABSTRACT:
SUBMITTER: Stanek O
PROVIDER: S-EPMC7551409 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Stanek Ondrej O Linhartova Irena I Holubova Jana J Bumba Ladislav L Gardian Zdenko Z Malandra Anna A Bockova Barbora B Teruya Shihono S Horiguchi Yasuhiko Y Osicka Radim R Sebo Peter P
Toxins 20200915 9
Pathogenic <i>Bordetella</i> bacteria release a neurotropic dermonecrotic toxin (DNT) that is endocytosed into animal cells and permanently activates the Rho family GTPases by polyamination or deamidation of the glutamine residues in their switch II regions (e.g., Gln63 of RhoA). DNT was found to enable high level colonization of the nasal cavity of pigs by <i>B. bronchiseptica</i> and the capacity of DNT to inhibit differentiation of nasal turbinate bone osteoblasts causes atrophic rhinitis in ...[more]