Ontology highlight
ABSTRACT:
SUBMITTER: Pal D
PROVIDER: S-EPMC7552110 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Pal Deeksha D Kolluru Venkatesh V Chandrasekaran Balaji B Baby Becca V BV Aman Masarath M Suman Suman S Sirimulla Suman S Sanders Mary Ann MA Alatassi Houda H Ankem Murali K MK Damodaran Chendil C
Molecular carcinogenesis 20161105 3
We have previously reported that high aldehyde dehydrogenase (ALDH) enzyme activity in breast cancer cells results in breast cancer stem cell (BCSC) properties by upregualting Notch-1 and epithelial mesenchymal markers. This results in chemoresistance in breast cancer. Here, we examined the functional and clinical significance of ALDH expression by measuring the ALDH levels in breast cancer tissues by immunohistochemistry. There was a significantly higher ALDH expression in higher grade breast c ...[more]