Dataset Information

The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition.

ABSTRACT: Introduction:Cognitive decline in Alzheimer's disease is associated with amyloid beta (A?) accumulation, neurodegeneration, and cerebral small vessel disease, but the temporal relationships among these factors is not well established. Methods:Data included white matter hyperintensity (WMH) load, gray matter (GM) atrophy and Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS13) scores for 720 participants and cerebrospinal fluid amyloid (A?1-42) for 461 participants from the Alzheimer's Disease Neuroimaging Initiative. Linear regressions were used to assess the relationships among baseline WMH, GM, and A?1-42 to changes in WMH, GM, A?1-42, and cognition at 1-year follow-up. Results:Baseline WMHs and A?1-42 predicted WMH increase and GM atrophy. Baseline WMHs and A?1-42 predicted worsening cognition. Only baseline A?1-42 predicted change in A?1-42. Discussion:Baseline WMHs lead to greater future GM atrophy and cognitive decline, suggesting that WM damage precedes neurodegeneration and cognitive decline. Baseline A?1-42 predicted WMH increase, suggesting a potential role of amyloid in WM damage.

SUBMITTER: Dadar M

PROVIDER: S-EPMC7552231 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition.

Dadar Mahsa M Camicioli Richard R Duchesne Simon S Collins D Louis DL

Alzheimer's & dementia (Amsterdam, Netherlands) 20201013 1

<h4>Introduction</h4>Cognitive decline in Alzheimer's disease is associated with amyloid beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the temporal relationships among these factors is not well established.<h4>Methods</h4>Data included white matter hyperintensity (WMH) load, gray matter (GM) atrophy and Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS13) scores for 720 participants and cerebrospinal fluid amyloid (Aβ1-42) for 461 participants from the ...[more]

PMID: 33083512

Similar Datasets

Project description:BackgroundPatients with Parkinson's disease (PD) present with a broad spectrum of nonmotor features including autonomic disorders. More severe autonomic dysfunction in PD is associated with increased cognitive deficits. The presence of cerebral small-vessel disease, measured by T2-weighted magnetic resonance imaging white matter hyperintensity (WMH) burden, is also observed in patients with PD with faster cognitive decline.ObjectiveTo investigate whether baseline orthostatic hypotension and autonomic dysfunction in early-stage PD affect later cognitive decline via mediation through cerebral small-vessel disease.MethodsDe novo PD patients (N = 365) and age-matched controls (N = 174) with baseline T2-weighted/ fluid-attenuated inversion recovery scans were selected from the Parkinson's Progression Markers Initiative. WMHs were automatically segmented. Mediation analysis was used to assess whether WMH load mediates the effect of orthostatic hypotension and autonomic dysfunction (measured by Scales for Outcomes in Parkinson's Disease-Autonomic) on future cognitive decline (measured by Montreal Cognitive Assessment) in an average of 4 years of follow-up.ResultsMediation analysis supported the existence of a full mediation of WMHs on the effect of diastolic orthostatic hypotension in patients with PD and future cognitive decline (average causal mediation effect: ab = -0.032, 95% confidence interval = -0.064 to -0.01, P = 0.01). There was also a partial mediation for overall autonomic dysfunction (ab = -0.027, 95% confidence interval = -0.054 to 0.00, P = 0.02).ConclusionsWMHs fully mediate the effect of diastolic orthostatic hypotension and partially mediate the effect of autonomic dysregulation on future cognitive decline in patients with PD. Our findings support the hypothesis that autonomic dysfunction in early clinical stages predisposes the brain to WMHs through dysregulation of the blood flow in the small vessels. This in turn increases the risk of future cognitive impairment in early PD.

Dataset Information

The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition.

Publications

The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets