Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC7552397 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Muziying M Zhou Kang K Xu Zhihao Z Ma Huan H Cao Xiaocong X Yin Xueying X Zeng Weihong W Zahid Ayesha A Fu Sicheng S Ni Kang K Ye Xiaodong X Zhou Ying Y Bai Li L Zhou Rongbin R Jin Tengchuan T
Cell discovery 20201013
Murine caspase-11 is the centerpiece of the non-canonical inflammasome pathway that can respond to intracellular LPS and induce pyroptosis. Caspase-11 contains two components, an N-terminal caspase recruitment domain (CARD) and a C-terminal catalytic domain. The aggregation of caspase-11 is thought to promote the auto-processing and activation of caspase-11. However, the activation mechanism of caspase-11 remains unclear. In this study, we purified the caspase-11 CARD fused to an MBP tag and fou ...[more]