Ontology highlight
ABSTRACT:
SUBMITTER: Jiang H
PROVIDER: S-EPMC7552407 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Jiang Huimin H Zhou Chen C Zhang Zhen Z Wang Qiong Q Wei Huimin H Shi Wen W Li Jianjun J Wang Zhaoyang Z Ou Yang Y Wang Wenhao W Wang Hang H Zhang Quansheng Q Sun Wei W Sun Peiqing P Yang Shuang S
Nature communications 20201012 1
Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemness, colonization and the phenotypic plasticity of breast cancer. Moreover, we demonstrate that, with direct cell-cell contact, TME-derived endothelial cells provide the Notch ligand ...[more]