The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing.
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ABSTRACT:
SUBMITTER: Zubovic L
PROVIDER: S-EPMC7552545 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing.
Zubovic Lorena L Piazza Silvano S Tebaldi Toma T Cozzuto Luca L Palazzo Giuliana G Sidarovich Viktoryia V De Sanctis Veronica V Bertorelli Roberto R Lammens Tim T Hofmans Mattias M De Moerloose Barbara B Ponomarenko Julia J Pigazzi Martina M Masetti Riccardo R Mecucci Cristina C Basso Giuseppe G Macchi Paolo P
Journal of hematology & oncology 20201012 1
Pediatric myelodysplastic syndrome (PMDS) is a very rare and still poorly characterized disorder. In this work, we identified novel potential targets of PMDS by determining genes with aberrant expression, which can be correlated with PMDS pathogenesis. We identified 291 differentially expressed genes (DEGs) in PMDS patients, comprising genes involved in the regulation of apoptosis and the cell cycle, ribosome biogenesis, inflammation and adaptive immunity. Ten selected DEGs were then validated, ...[more]
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